In the rapidly growing field of viscosupplementation, keeping up with the latest clinical research can be difficult. We've assembled a comprehensive list of recent articles and scientific studies on the efficacy and safety of SYNVISC® to help you find the information you need.

SYNVISC Efficacy

1. Raman R, et al. Efficacy of Hylan G-F 20 and Sodium Hyaluronate in the treatment of osteoarthritis of the knee — A prospective randomized clinical trial, The Knee (2008), doi:10.1016/j.knee.2008.02.012

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2. Wang C-T, Lin J, Chang C-J, Lin Y-T, Hou S-M. Therapeutic effects of hyaluronic acid on osteoarthritis of the knee: a meta-analysis of randomized controlled trials. J Bone Joint Surg.2004; 86-A: 538-545.

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3. Wobig M, Dickhut A, Maier R, Vetter G. Viscosupplementation with hylan G-F 20: A 26 week controlled trial of efficacy and safety in the osteoarthritic knee. Clin Ther. 1998; 20:410-423.

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4. Caborn D, Rush J, Lanzer W, Parenti D, Murray C, on behalf of the Synvisc 901 Study Group. A randomized, single-blind comparison of the efficacy and tolerability of hylan G-F 20 and triamcinolone hexacetonide in patients with osteoarthritis of the knee. J Rheumatol.2004; 31:333-343.

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5. Bagga H, Burkhardt D, Sambrook P, March L. Long-term effects of intra-articular hyaluronan on synovial fluid in osteoarthritis of the knee. J Rheumatol. 2006; 33:946-950.

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SYNVISC Safety

6. Kemper F, Gebhardt U, Meng T, Murray C. Tolerability and short-term effectiveness of hylan G-F 20 in 4253 patients with osteoarthritis of the knee in clinical practice. Curr Med Res Opin.2005; 21:1261-1269.

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7. Waddell DD. The tolerability of viscosupplementation: low incidence and clinical management of local adverse events. Curr Med Res Opin.2003; 19:575-580.

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8. Raynauld J, Goldsmith C, Bellamy N, Torrance G, Polisson R, Belovich D, Pericak D, Tugwell P. Effectiveness and safety of repeat courses of hylan G-F 20 in patients with knee osteoarthritis. Osteoarthritis & Cartilage. 2005; 13:111-119.

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9. Waddell DD, Bricker DC. Hylan G-F 20 tolerability with repeat treatment in a large orthopedic practice: A retrospective review. J Surg & Orthopaedic Advances. 2006; 15(1):53-59.

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10. Waddell DD, Cefalu C, Bricker DC. A second course of hylan G-F 20 for the treatment of osteoarthritic knee pain: 12-month patient follow-up. J Knee Surg. 2005; 18:7-15.

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