Clinical Insights
The efficacy and safety of viscosupplements have been well documented. Less well-understood,
however, may be how SYNVISC® compares with other viscosupplements.
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Viscosupplements for Osteoarthritis Knee Pain:
A meta-analysis evaluating magnitude of pain relief
The efficacy and tolerability of viscosupplements for the treatment of osteoarthritis knee pain has been well established in a number of clinical trials. However, until recently, no analysis existed that provided physicians with insight into the magnitude of pain relief that viscosupplements provide.
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The Magnitude of Pain Relief with SYNVISC® (hylan G-F 20) as Demonstrated in 3 Well-Controlled Trials
Included in guidelines for the treatment of osteoarthritis (OA) knee pain , viscosupplementation has become an established therapy in the United States. Somewhat less established, however, may be the criteria that physicians must consider when determining which viscosupplement to use. These criteria may include efficacy and safety profiles, clinical experience, and treatment schedule.
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Clarifying Tolerability Issues in Viscosupplementation for Osteoarthritis Knee Pain
Numerous well-controlled clinical trials, as well as a retrospective chart review, have shown that treatment for osteoarthritis (OA) knee pain with SYNVISC (hylan G-F 20) has a low incidence of local adverse events (AEs)—an incidence consistent with current product labeling. , , , However, the frequency, severity, and management of these events have been a subject of some discussion among clinicians.
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