In the rapidly growing field of viscosupplementation, keeping up with the latest clinical research can be difficult. To help you find the information you need, we’ve assembled a comprehensive list of recent articles and scientific studies on the efficacy and safety of SYNVISC®.
SYNVISC Efficacy
1. Raman R, Dutta A, Day N, Shaw CJ, Johnson GV. The efficacy of hylan G-F 20 and sodium hyaluronate in the treatment of
osteoarthritis of the knee—a prospective randomized clinical trial. Poster presented at: American College of Rheumatology
Annual Scientific. Meeting; November 10-15, 2006; Washington, DC.
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2. Wang C-T, Lin J, Chang C-J, Lin Y-T, Hou S-M. Therapeutic effects of hyaluronic acid on osteoarthritis of the knee:
a meta-analysis of randomized controlled trials. J Bone Joint Surg.2004; 86-A: 538-545.
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3. Wobig M, Dickhut A, Maier R, Vetter G. Viscosupplementation with hylan G-F 20: A 26 week controlled trial of efficacy
and safety in the osteoarthritic knee. Clin Ther. 1998; 20:410-423.
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4. Caborn D, Rush J, Lanzer W, Parenti D, Murray C, on behalf of the Synvisc 901 Study Group. A randomized, single-blind comparison of
the efficacy and tolerability of hylan G-F 20 and triamcinolone hexacetonide in patients with osteoarthritis of the knee.
J Rheumatol.2004; 31:333-343.
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5. Bagga H, Burkhardt D, Sambrook P, March L. Long-term effects of intra-articular hyaluronan on synovial fluid in osteoarthritis of the knee. J Rheumatol. 2006; 33:946-950.
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SYNVISC Safety
6. Kemper F, Gebhardt U, Meng T, Murray C. Tolerability and short-term effectiveness of hylan G-F 20 in 4253 patients with osteoarthritis
of the knee in clinical practice. Curr Med Res Opin.2005; 21:1261-1269.
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7. Waddell DD. The tolerability of viscosupplementation: low incidence
and clinical management of local adverse events. Curr Med Res Opin.2003; 19:575-580.
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8. Raynauld J, Goldsmith C, Bellamy N, Torrance G, Polisson R, Belovich D, Pericak D, Tugwell P. Effectiveness and safety of repeat courses of hylan G-F 20 in patients with knee osteoarthritis. Osteoarthritis & Cartilage. 2005; 13:111-119.
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9. Waddell DD, Bricker DC. Hylan G-F 20 tolerability with repeat treatment in a large orthopedic practice: A retrospective review. J Surg & Orthopaedic Advances. 2006; 15(1):53-59.
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10. Waddell DD, Cefalu C, Bricker DC. A second course of hylan G-F 20 for the treatment of osteoarthritic knee pain: 12-month patient follow-up. J Knee Surg. 2005; 18:7-15.
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