SYNVISC is injected directly into the knee joint in three injections, one week apart.

• May provide up to six months of knee pain relief
• Some patients experience pain relief after the first injection
• Most patients feel the greatest relief after 8-12 weeks (if they've had all three SYNVISC hyaluronan injections)

SYNVISC is administered locally and has a proven safety profile. Local adverse events with SYNVISC are generally mild to moderate, easily managed, and do not preclude clinical benefit.^1,2,3 Watch a 3D animation showing the SYNVISC hyaluronan injection process below.

1. Kemper F, Gebhardt U, Meng T, Murray C. Tolerability and short-term effectiveness of hylan G-F 20 in 4253 patients with osteoarthritis of the knee in clinical practice. Curr Med Res Opin. 2005;21(8):1261-1269

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2. Waddell DD, Bricker DC. Hylan G-F 20 tolerability with repeat treatment in a large orthopedic practice: a retrospective review. J Surg Orthop Adv. 2006;15(1):53-59

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3. Lussier A et al. J Rheumatol. 1996;23:1579-1585.

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